The purpose of this study was to formulations for topical delivery of ibuprofen. Ethyl oleate (EO)

The purpose of this study was to formulations for topical delivery of ibuprofen. Ethyl oleate (EO) was screened as the oil phase microemulsiocs, a good solvent for the capacity of the system and the skin permeation rate microemulison excellent ibuprofen. Pseudo-ternary phase diagrams for microemulsion regions constructed using ethyl oleate as oil, Tween 80 as surfactant, propylene glycol as the cosurfactanx. Various microemulsion formulations prepared and the ability to provide a wide range of microemulsion ibuprofen through the skin were evaluated in vitro using Franz diffusion cells fitted with pig skin. In vitro permeation of the data showed that the rate of permeation of ibuprofen microemulsion increase from 5.72 to 30.0 times until the solution is saturated. Optimal formulation consisted dorner of ibuprofen dorner 3%, 6% EO, 30% Tween 80/PG (2:1) and water, showed a high permeation rate 38.06 mg cm -2 h -1. Xanthan as gel matrix dorner used to build the microemulsion-based hydrogel to increase the viscosity of the microemulsion for topical administration. In the studied microemulsion-based hydrogel showed good stability. These results indicate that the microemulsion-based hydrogel study may hold promise for topical delivery of ibuprofen.
Microemulsion is defined as the dispersion phase consisting of oil, surfactant, cosurfactant and aqueous phase, which is a liquid solution of a single optical isotropic and thermodynamically stable droplets with diameters typically in the range of 10-100 nm (Tenjarla, 1999). Microemulsion has several advantages such as enhanced drug solubility, good thermodynamic dorner stability, the effect of increasing the ability to more conventional transdermal mulations (Lawrence and Rees, 2000). There are several mechanisms of microemulsion enhencement shift as the concentration gradient increases and the thermodynamic activity and activity against skin permeation enhancement component microemulsion (Peltola et al., 2003). So far much attention has been focused on the topical delivery of drugs such as estradiol and lidocaine using a microemulsion (Peltola et al, 2003;. Sintov and Shapiro, 2004). In contrast to recent, such as Carbomer hydrogel matrix 940, xanthan gum and carrageenan has been used to increase the viscosity of the microemulsion for topical application (Lapasin et al, 2001;. Peltola et al, 2003; .. Spiclin et al, 2003, Valenta and Schultz, 2004; Gulsen and Chauhan, 2005). The addition of a hydrogel matrix to result in the formation of microemulsion microemulsion-based hydrogel, dorner which is more suitable for topical application when compared to the microemulsion.
Ibuprofen, a non-steroidal anti-inflammatory (NASAID) are very effective for the treatment of systemic rheumatoid arthritis, osteoarthritis dorner and ankylosing spondylitis. dorner Ibuprofen formulated into topical preparations mostly to reduce side effects and avoid the effects arising in the liver (hepatic first-pass metabolism). But it is difficult to maintain dorner an effective concentration of the topical delivery of ibuprofen as skin permeation ability ugly (Yano et al., 1986). In order to improve the permeation dorner of ibuprofen, saturated solution, eutectic systems, and vehicle mucoadhesive patch containing non-ionic surfactants or fatty acids have been explored (Stott et al., 1998; Park et al., 2000; Irevolino et al., 2001; Heard et al., 2003; Perioli dorner et al., 2004).
The purpose for developing topical microemulsion-based hydrogel over the long term this study focused on the screening of ibuprofen-loaded microemulsion and microemulsion formulations hydrogel-based construction
Ibuprofen dorner [2 - (4-isobutylphenyl)-propionic acid] were purchased from Zhongtian. Isopropyl myristate (IPM), isopropyl palmitate (IPP), oleic acid (OA), ethyl oleate (EO) and propylene glycol dorner (PG) were purchased from Shanghai Chemical Reagent Corporation (Shanghai, China). Tween 80 was obtained from Tianjin Bodi Chemical Company.
To find a suitable oil that can be used as an oil phase in mikroemulsion and provide excellent skin permeation rate of ibuprofen, ibuprofen solubility in a variety of oils including IPM, IPP, OA and EO were measured. The solubility of ibuprofen in the oil mixture were also measured. Obtained with a 1:10:5 mixture of oil mixed with oil: Tween 80: PG.Jumlah excess ibuprofen added to each oil and oil mixture, and then mixed with a magnetic stirrer. After stirring for 72 h at 25 C, equilibrated samples were centrifuged for 10 min at 12,000 dorner rpm to remove dorner excess amounts dorner of ibuprofen. Then the supernatant was filtered through a membrane filter, then diluted with methanol and concentration of ibuprofen were determined by HPLC. Various oils are also used in the preparation dorner be